STIMULATION AND INHIBITION OF DNA SYNTHESIS AND CELL GROWTH BY PARAQUAT IN CULTURED CELLS
スポンサーリンク
概要
- 論文の詳細を見る
Paraquat, a popular herbicide, is known to be very toxic to man and animals. Using cultured mammalian cells (human embryo lung cell, R-66), the effect of paraquat has been studied. With autoradiography, stimulation of DNA synthesis was observed when the cells were exposed to 0.08 or 0.4μM of paraquat; however, DNA synthesis was inhibited with 40 μM of paraquat. To determine cell growth rate, accumulation of mitotic cells was determined after addition of colcemid (0.2μg/ml) into the culture medium. The ratios of mitotic cells observed were proportional to the level of DNA synthesis. And the stimulation and inhibition of cell growth were observed even after washing off paraquat from media.
- 日本トキシコロジー学会の論文
- 1985-11-25
著者
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Amano Yukinori
Fuji Research Laboratories Pharmaceutical Division Kowa Company Ltd.
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TANAKA Reiko
Department of Infections, Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba Univer
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Tanaka R
Biosafety Res. Center Shizuoka Jpn
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Amano Yasuji
Fuji Research Laboratories Pharmaceutical Division Kowa Company Ltd.
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AMANO Yasuji
Akita University School of Medicine
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Tanaka Reiko
Department Of Pharmacology And Central Laboratory
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Tanaka Reiko
Department Of Endocrine Surgery Tokyo Women's Medical College
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