Protective Effects of (-)Epigallocatechin Gallate and (+)Catechin on Nitrogen Oxide-Induced Sister Chromatid Exchange
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概要
- 論文の詳細を見る
The protective effects of green tea polyphenols on nitrogen oxide (NOx) -induced sister chromatid exchange (SCE) in cultured cells were studied. (-) Epigallocatechin gallate (EGCG) and (+) catechin (CT), the major polyphenol constituents of green tea, were found to reduce the frequency of SCE induced by NOx. NO releaser (NOR4) -released NO and NaNO_2 were used as NOx. Significantly fewer SCEs were induced by 30 _μM NOR4 and NaNO_2 after the treatment of cells with 0.1 _μM EGCG or 0.5 _μM CT. NOx (NO, NO_2^-) is a potent environmental pollutant owing to its carcinogenic properties. Therefore these experimental results indicate the protective effects of green tea against NOx-type carcinogens.
- 2005-02-01
著者
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Tanaka Reiko
秋田看護福祉大学 看護学科
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TANAKA Reiko
Department of Infections, Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba Univer
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Tanaka R
Tokai Univ. Shimizu Jpn
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Tanaka Reiko
Department Of Endocrine Surgery Tokyo Women's Medical College
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