TOXICOLOGICAL STUDIES ON AMFENAC SODIUM (AHR-5850) : (I) ACUTE TOXICITIES IN MICE AND RATS
スポンサーリンク
概要
- 論文の詳細を見る
Acute toxicities of Amfenac sodium (AHR-5850), new non-steroidal anti-inflammatory agent, were studied in mice and rats. Each value of LD_<50> by oral, sc, im, iv and ip administration with this compound was 1190, 580, 540, 550 and 790 mg/kg for male mice and 1450, 625, 610, 630 and 710 mg/kg for female mice, respectively. Rats showed higher lethality than mice. There was no significant difference of sex in the values of LD_<50> for mice and rats. movement and respiration rate followed by gastrointestinal ulcer, secondary peritonitis and systemic emaciation. These results suggest that the death is caused by secondary petitonitis and systemic emaciation due to gastrointestinal ulcer.
- 日本トキシコロジー学会の論文
- 1984-02-25
著者
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SASAKI Hitoshi
Laboratory of Entomology, Graduate school of Rakuno Gakuen University
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Wada Tohru
Laboratory of Marine Chemistry, Faculty of Fisheries, Hokkaido University
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Wada Tohru
Laboratory Of Marine Chemistry Faculty Of Fisheries Hokkaido University
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Wada Tohru
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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KOEDA TAKEMI
Laboratory of Pharmacology, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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Kawaoto Haruo
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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Koeda Takemi
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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Koeda Takemi
Laboratory Of Pharmacology Central Research Laboratories Meiji Seika Kaisha Ltd.:(present Address)la
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Koeda Takemi
Central Research Laboratories Meiji Seika Kaisha Ltd.:(present Address) Kobe Women's College Of
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Yokota Masayuki
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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Odaki Masuzo
Laboratory of Toxicology, Central Research Laboratories of Meiji Seika Kaisha Ltd.
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Watanabe Hiroshi
Laboratory of Toxicology, Central Research Laboratories of Meiji Seika Kaisha Ltd.
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Itoh Takashi
Laboratory of Toxicology, Central Research Laboratories of Meiji Seika Kaisha Ltd.
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Ishiwatari Nobuyoshi
Laboratory of Toxicology, Central Research Laboratories of Meiji Seika Kaisha Ltd.
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Seki Michihiko
Laboratory of Toxicology, Central Research Laboratories of Meiji Seika Kaisha Ltd.
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Takeda Ueto
Laboratory of Toxicology, Central Research Laboratories of Meiji Seika Kaisha Ltd.
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Odaki Masuzo
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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Seki Michihiko
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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Takeda Ueto
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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Ishiwatari Nobuyoshi
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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Sasaki Hitoshi
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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Sasaki Hitoshi
Laboratory Of Entomology Graduate School Of Rakuno Gakuen University
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Sasaki Hitoshi
Laboratory Of Entomology Department Of Dairy Science Rakuno Gakuen University
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Yokota Masayuki
Dept. Of Pharmacology And Toxicology Central Research Lab. Meiji Seika Kaisha
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Ito Takashi
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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Watanabe Hiroshi
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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