PROTECTIVE EFFECT OF FOSFOMYCIN ON THE EXPERIMENTAL NEPHROTOXICITY INDUCED BY DIBEKACIN
スポンサーリンク
概要
- 論文の詳細を見る
Protection by fosfomycin of the nephrotoxicity of dibekacin was studied using Fischer 344 rats and urinary parameters such as volume, osmolality, protein, N-acetyl-β-D-glucosaminidase, leucine aminopeptidase, lactate dehydrogenase and nucleated cells were determined as markers of nephrotoxicity. The duration of treatment was 11 d. Fosfomycin reduced polyuria, proteinuria, enzymuria and cyturia induced by dibekacin best by the concomitant administration, followed by pre-treatment, but not by post-treatment. Protection was effective in the dose ratio of dibekacin : fosfomycin=1 : 2-1 : 32,regardless of administration routes. As judged from urinalysis, protection by fosfomycin (320 mg/kg) was almost complete for the experimental nephrotoxicity induced by 10 mg/kg of dibekacin, and still significant for that by 40 mg/kg. This was supported by the histo-pathological and ultrastructural improvement of proximal tubules and by suppressed blood urea nitrogen and creatinine values. Protective activity of fosfomycin was more potent than that of cephalothin, when compared on the weight basis.
- 公益社団法人日本薬学会の論文
著者
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Koeda Takemi
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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Koeda Takemi
Central Research Laboratories Meiji Seika Kaisha Ltd.:(present Address) Kobe Women's College Of
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Niizato Tetsutaro
Department Of Pharmacology And Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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Niizato Tetsutaro
Central Research Laboratories Meiji Seika Kaisha Ltd.
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Inouye Shigeharu
Central Research Laboratories Meiji Seika Kaisha Ltd.
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Takeda Ueto
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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TAKEDA Ueto
Central Research Laboratories, Meiji Seika Kaisha
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Takeda Ueto
Central Research Laboratories Meiji Seika Kaisha Ltd.
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