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Kremezin, which is an adsorbent, is used to treat the uremia symptoms of chronic renal failure and to prolong before introduction of dialysis. These patients are obliged to take as much as 10 capsules of Kremezin at one time, which is difficult for them due to their restricted fluid intake and would reduce their QOL. In order to find a better way to administer Kremezin, we investigated 10 patients (average age : 59.1±13.8)with diabetic nephropathy who were taking Kremezin capsules. Although all were uncomfortable with the size and number of capsules, they were taking 5 capsules twice a day (10 capsules in total) with about 30 ml of water at one time. Apparently,a healthy volunteer could take 5 capsules with 30 ml of water as well as the patients. Roentgenograms, however, showed that some of the capsules were retained in narrow part of esophagus near bronchial furcation in the volunteer unless they took an additional 30 ml of water. It has been shown that 10 capsules of Kremezin can be taken by dividing them into two 5 capsule portions with 30 ml of water, but in order to transit all capsules to stomach completely it is necessary to drink additional water (about 30 ml) immediately after taking the capsules.
1998-12-10