相互作用を示す薬剤の簡便なチェックシステム

概要

論文の詳細を見る
Potential adverse effects in combinations of multiple drug usage are well known, and have been available on each product information. However, it has not been well established how to combine these informations useful in the process of routine prescriptions. In order to overcome these difficulties, a system using a personal computer and a commercially available data base program (dBXL) is developed. Using the system, the prescriptions of 1,511 inpatients in the 2 wards served for the department of internal medicine in our hospital were analyzed. The survey was done during a period of June 1991 to May 1992, including 6924 different drugs. Of these prescriptions, 16.5% were found potentially hazardous due to drug interactions, except anti-tuberculosis agents. The highest 4 drugs prescribed with potential adverse interactions were anti-tuberculosis drugs, diuretics, anti-calcium antagonists and hypoglycemic drugs, respectively. Fortunately, none of these patients encountered with serious results of drug interactions. However, the results clearly indicate the necessity of a routine check system for potentially hazardous prescriptions with multiple drug usage. This simple and inexpensive system developed will be useful until a complete ordering system becomes available.
日本医療薬学会の論文
1993-06-21