1,9-Nonanedialおよび2-Methyl-1,8-octanedialのB型肝炎ウイルス表面抗原に及ぼす影響
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概要
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1,9-Nonanedial (NDL) and 2-methyl-1,8-octanedial (NDL : 2-methyl-1,8-octanedial=1 : 1, INDL) belong to dialdehyde compounds as well as glutaraldehydes, and it is presumed to show the similar reactivity to Hepatitis B virus. Hepatitis B virus surface antigen (HBsAg) was treated with 0.04 mM NDL, 0.04 mM INDL, 0.04 mM glutaraldehyde and 10% formalin solution, and the titer was determined according to the method of radioimmunoassay. HbsAgs were as follows : PLC/PRF/5 cells cultured medium, Purified HBsAs coated beads and HbeAg Positive Sera. NDL, INDL and glutaraldehyde (adjusted to pH 8.0 respectively) indicated the reduction of antigenicity of HBsAg (cultured medium and beads), but formalin did not. Moreover, NDL reduced the titer of HBsAg (HBeAg positive sera) to half for at least 10 minutes. These results suggest that NDL and INDL may be employed for disinfectant to Hepatitis B virus.
- 日本医療薬学会の論文
- 1986-08-20
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