毛髪中の薬物分析 : 覚醒剤使用歴のモニタリンケを目的として

概要

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Hair analysis for monitoring a long-term drug abuse history was studied. Determination method of methamphetamine and amphetamine in hair was developed by gas chromatography/mass spectrometry using stable isotope labeled internal standards. Fairly good reproducibility and accuracy were obtained due to a use of stable isotope internal standards. Determination limit is less than 0.5ng/mg. Sectional analysis of monkey hair grown for 8 weeks after the first 3 week methamphetamine administrations provided good correlation between duration of drug use and drug distribution along the hair shaft. Furthermore, methamphetamine abuser's hair samples were analysed. Drug concentrations in 2 cm segments along hair shaft were compared to self reported drug histories of 11 cases. As the results, in ten of 11 cases, the relationship between the results of sectional analysis and drug histories coincided. Our study suggests that sectional hair analysis may be useful in monitoring drug history even though it is not very accurate.
日本医療薬学会の論文
1990-10-20