An Additional Form of Rat Bcl-x, Bcl-xβ, Generated by an Unspliced RNA, Promotes Apoptosis in Promyeloid Cells
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概要
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The bcl-2 oncogene product delays apoptotic cell death and prolongs the cell survival. We cloned two bcl-2-related cDNAs from a rat thymus cDNA library by low stringency hybridization with a rat bcl-2 fragment as a probe. One of these, designated bcl-χα, was a counterpart of the human bcl-χ_L reported previously as a bcl-2-related gene (Boise, L. H., Gonzalez-Garcia, M., Postema, C. E., Ding, L., Lindsten, T., Turka, L. A., Mao, M., Nunez, G., and Thompson, C. B. (1993) Cell 74,597-608). The other, designated bcl-χβ, was novel and found to be generated by an unspliced mRNA, whereas bcl-χα was generated from a spliced transcript. The splice junction exactly corresponded to that found in the bcl-2 gene. bcl-χβ was specifically expressed in cerebellum, heart, and thymus. When bcl-χβ directed by a strong promoter was introduced into an interleukin-3-dependent promyeloid cell line, FDC-P1,DNA fragmentation was observed even in the growing state in the presence of interleukin-3 although not in the control transfectants. This finding suggests that the rat bcl-xβ gene product promotes apoptosis in the promyeloid cells.
- 日本医科大学の論文
- 1997-03-25
著者
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Ohta Shigeo
Department of Biochemistry and Cell Biology, Institute of Development and Aging Science, Graduate Sc
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Ohta Shigeo
Department Of Biochemistry And Cell Biology Institute Of Development And Aging Science Graduate Scho
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Okada Seiji
Department Of Developmental Genetics Chiba University Graduate School Of Medicine
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YUZAKI Michisuke
Department OF Physiology, School of Medicine, Keio University
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Shiraiwa Nobuko
Department of Biochemistry, Jichi Medical School
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Inohara Naohiro
Division of Biochemistry, Institute of Gerontology, Nippon Medical School
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Shiraiwa Nobuko
Department Of Biochemistry Jichi Medical School
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Shiraiwa Nobuko
Department Of Biochemistry Jichi Medical School:(present Address) Dept. Of Neurology Inst. Of Medici
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Ohta Shigeo
Department Of Biochemistry Jichi Medical School:division Of Biochemistry Institute Of Gerontology Ni
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Shoji Shinichi
Department of Neurology, Institute of Medicine, Tsukuba University
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Shoji Shinichi
Department Of Neurology Institute Of Medicine Tsukuba University
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Okada Seiji
Department Of 2nd. Internal Medicine Matsue City Hospital
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Okada Seiji
Department Of Biochemistry Jichi Medical School:(present Address) Dept. Of Hematology Jichi Medical
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Inohara Naohiro
Division Of Biochemistry Institute Of Gerontology Nippon Medical School
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Yuzaki Michisuke
Department Of Biochemistry Jichi Medical School:(present Address) Dept. Of Developmental Neurobiolog
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