Bcl-2 Completely Blocks Fas-Mediated Apoptosis in mtDNA-Depleted HeLa Cells
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概要
- 論文の詳細を見る
Bcl-2 inhibits apoptosis induced by a variety of death stimuli but does not completely inhibit Fas-mediated apoptosis. We have previously shown that a HeLa-de-rived cell line lacking mitochondrial DNA (mtDNA) expresses Fas at a high level and apoptosis is easily induced using a low concentration of an anti-Fas antibody. In this study, overexpression of Bcl-2 in the mtDNA-less cells completely blocked Fas-mediated apoptosis, and this was not due to a depression of the enhanced Fas expression. These findings suggest that the Fas-mediated apoptotic pathway is directly linked to Bcl-2 protection in the cells with an accompanying mitochondrial dysfunction.
- 日本医科大学の論文
- 1998-03-25
著者
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Ohta Shigeo
Department Of Biochemistry And Cell Biology Institute Of Development And Aging Science Graduate Scho
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Asoh Sadamitsu
Department Of Biochemistry And Cell Biology Institute Of Development And Aging Sciences Graduate Of
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Asoh Sadamitsu
Department Of Biochemistry And Cell Biology Institute Of Gerontology Nippon Medical School
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