Phosphorylation of Delta2 Glutamate Receptors at Serine 945 is Not Required for Cerebellar Long-term Depression
スポンサーリンク
概要
- 論文の詳細を見る
Long-term depression (LTD) of synaptic transmission at parallel fiber (PF)-Purkinje cell synapses is thought to regulate motor learning and memory formation in the cerebellum. Neuronal activity-evoked protein kinase C (PKC) activation is required for the induction of LTD. In addition, theδ2 glutamate receptor (GluRδ2), which is predominantly expressed at PF-Purkinje cell synapses, is indispensable for the induction of LTD; however, the mechanisms by which GluRδ2 regulates LTD and its relationship with PKC activation remain elusive. Interestingly, GluRδ2 is phosphorylated by PKC on serine 945 (Ser945) near its C-terminus and a postsynaptic protein S-SCAM, which could potentially regulate glutamate receptor trafficking and synaptic plasticity, binds to the extreme C-terminus of GluRδ2 in a phosphorylation-dependent manner on Ser945. Here, using a Sindbis-based virus expression approach, we show that a mutant GluRδ2, in which alanine replaced Ser945 and did not undergo PKC phosphorylation, was normally localized at the postsynaptic sites of PF-Purkinje cell synapses. In addition, like wild-type GluRδ2, the phosphorylation-disrupted GluRδ2 successfully rescued abrogated LTD in GluRδ2-null Purkinje cells. These results indicate that Ser945, a major PKC phosphorylation site of of GluRδ2, may not play a crucial role in induction of LTD in the cerebellum.
- The Keio Journal of Medicineの論文
- 2008-06-01
著者
-
KATO Nobumasa
Department of Psychiatry, Showa University School of Medicine
-
Kato Nobumasa
Department Of Neuropsychiatry Faculty Of Medicine University Of Tokyo
-
Kato Nobumasa
Department Of Psychiatry University Of Tokyo
-
Kondo Tetsuro
Department Of Physiology School Of Medicine Keio University
-
YUZAKI Michisuke
Department OF Physiology, School of Medicine, Keio University
-
KOHDA KAZUHISA
Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo
-
Kohda Kazuhisa
Department Of Physiology School Of Medicine Keio University
-
NAKAGAMI Ryoichi
Department of Physiology, School of Medicine, Keio University
-
KAKEGAWA Wataru
Department of Physiology, School of Medicine, Keio University
-
Kakegawa Wataru
Department Of Physiology School Of Medicine Keio University
-
Nakagami Ryoichi
Department Of Physiology School Of Medicine Keio University
-
Yuzaki Michisuke
Department Of Physiology School Of Medicine Keio University
-
Yuzaki Michisuke
Department Of Biochemistry Jichi Medical School:(present Address) Dept. Of Developmental Neurobiolog
-
Nakagami Ryoichi
Department Of Neuropsychiatry Graduate School Of Medicine University Of Tokyo
関連論文
- Increased Plasma Urotensin-II and Carotid Atherosclerosis are Associated with Vascular Dementia
- No evidence for significant association between GABA receptor genes in chromosome 15q11-q13 and autism in a Japanese population
- Tachykinin 1 (TAC1) gene SNPs and haplotypes with autism : A case-control study
- Serotonin transporter gene promoter polymorphism and autism : A family-based genetic association study in Japanese population
- No association of FOXP2 and PTPRZ1 on 7q31 with autism from the Japanese population
- Gastrin-releasing peptide receptor (GRPR) locus in Japanese subjects with autism
- Association analysis of HSP90B1 with bipolar disorder
- Prevalence of post-traumatic stress disorder in incarcerated juvenile delinquents in Japan
- Potential functional neural repair with grafted neural stem cells of early embryonic neuroepithelial origin
- Serum cholesterol, uric acid and cholinesterase in victims of the Tokyo subway sarin poisoning : A relation with post-traumatic stress disorder
- Association and interaction analyses of NRG1 and ERBB4 genes with schizophrenia in a Japanese population
- Association study of the dysbindin (DTNBP1) gene in schizophrenia from the Japanese population
- An Additional Form of Rat Bcl-x, Bcl-xβ, Generated by an Unspliced RNA, Promotes Apoptosis in Promyeloid Cells
- Multiple-time replicability of near-infrared spectroscopy recording during prefrontal activation task in healthy men
- Combined analysis of association between personality traits and three functional polymorphisms in the tyrosine hydroxylase, monoamine oxidase A, and catechol-O-methyltransferase genes
- Mitochondrial DNA sequence analysis of patients with 'atypical psychosis'
- Support for relationship between serum cholinesterase and post-traumatic stress disorder ; 5-year follow-ups of victims of the Tokyo subway sarin poisoning
- Post-traumatic stress disorder symptoms in victims of Tokyo subway attack : a 5-year follow-up study
- Executive and prefrontal dysfunction in unipolar depression : a review of neuropsychological and imaging evidence
- Effects of corollary discharge on event-related potentials during selective attention task in healthy men and women
- What causes seasonality of birth in schizophrenia?
- White matter hyperintensity detected by magnetic resonance imaging and lithium response in bipolar disorder : A preliminary observation
- A newly developed assay for melatonin using cells expressing human mel-1a receptor
- Fragile X carrier screening and FMR1 allele distribution in the Japanese population
- ^I-IMP SPECTと^F-FDG PETによって診断しえた老年期うつ病の一例
- Running fit and geralized tonic-clonic seizure are differently controlled by differently subtypes receptors in the brain stem (vol. 2)
- Reduced intracellular pH in the basal ganglia and whole brain measured by ^P-MRS in bipolar disorder
- Phosphorylation of Delta2 Glutamate Receptors at Serine 945 is Not Required for Cerebellar Long-term Depression
- Review of animal models for autism : implication of thyroid hormone
- Audiogenic seizure induces c-fos mRNA expression in the inferior colliculus and not in the hippocampus
- Association of the XBP1-116C/G polymorphism with schizophrenia in the Japanese population
- Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation
- Effects of sleep deprivation : The phosphorus metabolism in the human brain measured by ^P-magnetic resonance spectroscopy
- A search for a mutation in the tumour necrosis factor-alpha gene in narcolepsy
- Familial Paroxysmal Kinesigenic Choreoathetosis : An Electrophysiologic and Genotypic Analysis
- Neuropeptide Y and somatostatin participate differently in the seizure-generating mechanisms following trimethyltin-induced hippocampal damage
- Beneficial effects of FK506 for experimental temporal lobe epilepsy
- Polarized sorting of AMPA receptors of the somatodendritic domain is regulated by adaptor protein AP-4
- The δ2 glutamate receptor : 10 years later
- New insights into the structure and function of glutamate receptors : orphan receptor δ2 reveals its family's secrets
- Temporospatial patterns of COX-2 expression and pyramidal cell degeneration in the rat hippocampus after trimethyltin administration
- ^I-IMP SPECTと^F-FDG PETによって診断しえた老年期うつ病の一例
- Genetic and neuroimaging studies in schizophrenia
- Mutations in PRRT2 responsible for paroxysmal kinesigenic dyskinesias also cause benign familial infantile convulsions
- An association analysis of Per2 with panic disorder in the Japanese population
- Male Hatano High-Avoidance Rats Show High Avoidance and High Anxiety-Like Behaviors as Compared with Male Low-Avoidance Rats
- Association of the oxytocin receptor (OXTR) gene polymorphisms with autism spectrum disorder (ASD) in the Japanese population
- No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population
- Male Hatano High-Avoidance Rats Show High Avoidance and High Anxiety-Like Behaviors as Compared with Male Low-Avoidance Rats
- The Role of Parasympathetic Nervous System in Stress-Induced Gastric Ulcer Formation: A Comparative Study on SHR, WKY, Wistar and MSG (monosodium-L-glutamate)-Treated Rats
- Gene expression profiling of major depression and suicide in the prefrontal cortex of postmortem brains
- Periaortitis Associated with Anti-neutrophil Cytoplasmic Antibodies Induced by Bevacizumab Combination Therapy