エタノールアミンオレエート注射液の製剤方法の検討と臨床への適用

概要

論文の詳細を見る
5% ethanolamine oleate (EO) as sclerosant in the treatment of esophageal varices was prepared under various conditions, and the stability of the solution at room temperature for 7 or 8 weeks was studied. Oleic acid in EO was measured as an indicator for stability of the solution by means of gas chromatograph. It was found that dissolved oxygen-removed EO was more stable than untreated one. Neither treatment of N_2 gas exchange in vial cavity nor autoclaving was essential to keep the content of oleic acid in EO for 8 weeks. 24 (88.9%) out of 27 patients with esophageal varices treated with endoscopic embolization using 5% EO made by our pharmacy were successfully treated. Frequency of complications and abnormal laboratory findings after treatment with the solution showed a rate which is roughly similar to the results reported, by other researchers.
日本医療薬学会の論文
1985-10-20