ユビデカレノン製剤顆粒, 細粒に対する光安定性および光分解

概要

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A high performance liquid chromatograph (HPLC) was used for the quality test of Ubidecarenone (CoQ_<10>) products. CoQ_<10> products were exposed to light under 2000 lux for 29 days, and their stability to light was studied with HPLC. The results were as follows: 1) Good separation of CoQ_<10>. CoQ_9 and UC_9 was achieved with HPLC. 2) The amount of CoQ_<10> in granules and fine granules packed with Pile Packer Film was between 11% and 18% after 29-day exposure to light, whereas CoQ_<10> in granules in light shielded package and that in raw material powder picked with pile packer Film were 74% and 90%, respectively. 3) The main decomposition substance of the granules, the fine granules and raw material powder showed that the relative retention to CoQ_<10> was 0.49.
日本医療薬学会の論文
1983-10-20