各種ユビデカレノン製剤に対する光照射の影響

概要

論文の詳細を見る
We used a high performance liquid chromatograph (HPLC) for the quality tests of Ubidecarenoe (CoQ_10) products. Sample materials used were : 1 tablet, 2 sugar coated tabblets, 3 hard capsules, 2 soft capsules, 3 packs of granules and 1 pack of fine granules. The quality tests were conducted und erhe following conditions : model, LC-3A (shimadzu) ; column, Zorbax ODS (4.6mm×25cm) ; column temperature, 50°; mobile phase, 99.5% ethanol ; flow rate, 0.8ml/min ; detector, SPD-2A (Shimadzu) ; wavelength, 275 nm ; data processor, Chromatopac C-RIA (Shimadzu). CoQ_10 extracted by n-hexane was directly injected into the HPLC column. The amount of CoQ_10 was determined from a peak area on the chromatogram. CoQ_10 products were exposed t0 light under 2000 lux for 29 days, while the granules and the fine granules were packed with Pile Packer Film and the other samples in commercial packages ; their stability to light was measured with HPLC. The results were as follows : 1) Some sample products contained impurities, the structures of which have not been elucidated as yet. 2) CoQ_l0 in soft capsules were most unstable to light. 3) As a result of exposure to light, the amount of CoQ_10 in granule and fine granule products decreased considerably, whereas the amount of CoQ_10 in other samples remained almost unchanged.
日本医療薬学会の論文
1982-10-20