アルギン酸ナトリウム液中のポラプレジンクの安定性についての検討

概要

論文の詳細を見る
Cancer chemotherapy and radiation therapy-induced stomatitis often involves symptoms severe enough that the oral ingestion of food may become difficult. We therefore prepared a polaprezinc (zinc N-(3-aminopropionyl)-L-histidine) suspension dispersed in sodium alginate solution (P-AG) as a specific treatment and agent for the prophylaxis of severe stomatitis, and examined the chemical and physico-chemical stability of P-AG for clinical use. The chemical and physico-chemical stability of P-AG was established from its appearance, the percentage polaprezinc content and viscosity immediately after steam sterilization and uniformity after being left to stand for 14 days at 25 and 5℃. Similarly, these parameters were examined in photostability testing (40℃, 2000lux) for 14 days at the same time. As a result, a change in appearance was observed after steam sterilization according to photostability testing. However, the percentage of polaprezinc contents did not decline after either steam sterilization, photostability testing or after being left to stand for 14 days regardless of the storage temperature. On the other hand, the viscosity of P-AG declined after steam sterilization according to the findings of photostability testing.
日本医療薬学会の論文
2003-02-10