吸入用気管支拡張剤の配合性

概要

論文の詳細を見る
Compatibility and stability of sympathomimetic bronchodilators, clorprenaline hydrochloride (CP), isoproterenol hydrochloride (IP), orciprenaline sulfate (OP), salbutamol sulfate (SM) and trimetoquinol hydrochloride (TQ) with physiological saline, Bisolvon Solution or Alevaire were studied using a high pressure liquid chromatography. No visual change was observed when each solution of bronchodilator was mixed with physiological saline or Bisolvon Solution. And all of the bronchodilators maintained more than 96% of the initial amount in the mixed solution for 2 weeks at room temperature. When mixed with Alevaire, however, most of the bronchodilators except CP showed a decrease in content developing a brown color, and TQ and IP showed a marked decrease. It was considered that this observation was due to oxidative degradation of bronchodilators in Alevaire. It can be concluded that TQ, IP, OP and SM are incompatible with alkaline solutions.
日本医療薬学会の論文
1983-02-20