高速液体クロマトグラフィーによる吸入用液剤中の気管支拡張剤の定量

概要

論文の詳細を見る
High pressure liquid chromatographic determination of clorprenaline hydrochloride, isoproterenol hydrochloride, orciprenaline sulfate, salbutamol sulfate and trimetoquinol hydrochloride in inhalant preparations was made using a Zorbax ODS reverse phase column and acetonitrile-phosphate buffer (pH 2.3) as mobile phase. The peaks of the additives and decomposition products in the solutions on chromatograms did not interfere with those of the bronchodilators. The coefficients of variation for analytical values, calculated from 2 different concentrations of the bronchodilators, ranged from 0.3 to 2.9%・ Moreover, good recoveries (95.5-101.9%) were obtained from Alevaire or Bisolvon Solution. Thus, the methods can be applied to the evaluation of these inhalant preparations.
日本医療薬学会の論文
1983-02-20