1 ラット局所脳虚血におけるセボフルラン麻酔下での脳循環自己調節能(第473回大阪歯科学会例会)

概要

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Using a model of acute-phase infarction of the middle cerebral artery (MCA) in rats, we evaluated the effect of sevoflurane anesthesia on cerebral autoregulation. The capacity for cerebral autoregulation, as assessed by the relative slope ratio (RS) between mean arterial pressure (MAP) and cerebral blood flow, was evaluated in exsanguinated rats (Group I), rats under deep anesthesia with sevoflurane (Group II), and rats with MCA infarction under deep anesthesia with sevoflurane (Group III). Although the animals in Groups I and II exhibited similar RS within the range of 40 to 110 mmHg MAP, the ratio in Group III was higher than in the other two (p<0.05). These findings suggest that cerebral autoregulation deteriorates during the acute phase of cerebral ischemia.
大阪歯科学会の論文
2000-12-25