11 セボフルランによるプレコンディショニングの心筋保護は,虚血再灌流後のExtracellular signalregulated kinaseの活性化が必要である(第516回大阪歯科学会例会)

概要

論文の詳細を見る
Brief exposure to volatile anesthetics before prolonged ischemia exerts a cardioprotective effect. We investigated whether extracellular signal-regulated kinase (ERK) is involved in sevoflurane-induced preconditioning. Isolated perfused guinea pig hearts were subjected to 30min global ischemia and 120min reperfusion (CTL). Sevofluraneinduced preconditioning was elicited by administration of sevoflurane at one minimum alveolar concentration with 10min washout before ischemia (SEVO). Infarct size was significantly reduced in SEVO compared to CTL. Phosphorylation of ERK at 10min after reperfusion was significantly increased in SEVO compared with CTL. Activation of ERK plays an important role in sevoflurane-induced preconditioning. This work was supported in part by Grant 07-06 from Osaka Dental University Research Funds.
大阪歯科学会の論文
2009-03-25