In vitro clastogenicity of 19 organic chemicals found in contaminated water and 7 structurally related chemicals

概要

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We tested the clastogenicity of 19 organic chemicals reportedly found in contaminated water, and 7 structurally related chemicals. We used the in vitro chromosomal aberration test with the Chinese hamster cell line CHL/IU in the presence and absence of mouse liver S9 mix. Nine of the 26 chemicals were positive. Benzaldehyde was positive only in the absence of S9 mix. Five chemicals(1, 2-dichloroethane, 2, 4, 6-trichlorophenol, heptachlor, acetophenone, and biphenyl)were positive only in the presence of S9 mix. Three chemicals(1, 3-dichloropropene, pentachlorophenol, and cyclohexylamine)were positive in both the absence and presence of S9 mix. Seventeen chemicals, including dibutylphthalate, di(2-ethylhexyl)phthalate, and methoxychlor(which we now suspect to be endocrine disruptors), and geosmin(a major odorous chemical in water source)were negative in this study. All the chemicals mentioned above were water contaminants, except 1, 3-dichloropropene and cyclohexylamine, which were structural relatives of contaminants.
日本環境変異原学会の論文
1998-10-31