光学活性物質と生物 : 合成化学で何がわかったか

概要

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Recent development in the studies on the relationships between optically active bioregulators and organisms is reviewed with emphasis on the role of synthetic chemistry to provide pure enantiomers. The power of modern analytical methods was illustrated by determination of the absolute configuration of plakoside A, an immunosuppressive glycosphingolipid. Case studies on limatulone (a marine triterpene with antifeedant activity) and stigmolone (a microbial pheromone) revealed that bioregulators are not always enantiomerically pure. Diverse stereochemistry-bioactivity relationships among pheromones including japonilure, olean and sulcatol are discussed to show the importance of enantiomerism in exhibiting bioactivity.
2002-08-20