殺ダニ剤ヘキシチアゾクスの開発

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Hexythiazox [trans-5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxothiazolidine-3-carboxamide] is a new miticide effective for control of various kinds of mites. Discovery of a compound with weak miticidal activity among thiazolo [2, 3-b] triazine derivatives, which had fungicidal activity on diseases caused by Phycomycetes, initiated this study, and trials of cleavages at a few parts of the triazine ring led to an invention of 2-thiazolidone compounds with outstandingly high acaricidal activity. In regard to the diastereoisomers at the 4- and 5-positions of the thiazolidine ring, the trans-form was found to be crucial for their miticidal activity. Introduction of various substituents, especially halogen atoms, onto the phenyl ring at the 5-position resulted in a remarkable improvement of the activity. A compound was selected from a large number of the derivatives, which has been in the market under the common name of hexythiazox. Hexythiazox had broad miticidal spectrum and excellent ovicidal, larvicidal and nymphcidal actions. It showed hatching inhibition through adult females and acted as both stomach and contact poisons on larvae. Immature mites treated with the compound did not die at the motile stage but died at the next chrysalis. Hexythiazox, possessed good residual activity and was successful in controlling citrus red mites for about 70 days in the field trial when used at very low concentrations of 25-50ppm. It has been confirmed that the miticide gives no lethal effect on predacious mites.
日本農薬学会の論文
1987-05-20

殺ダニ剤ヘキシチアゾクスの開発

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