抵抗性ツマグロヨコバイに対する N-プロピルカーバメート類の作用機構に関する研究

概要

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The green rice leafhoppers, Nephotettix cincticeps Uhler, have developed cross-resistance to many N-methylcarbamate insecticides due to the reduced sensitivity of its acetylcholinesterase (AChE) to the carbamates. We tried to develope new carbamates which could control such resistant leafhopper, and made various structural modifications which would increase the interaction with such altered AChE. Aryl N-propylcarbamates were found to be potent inhibitors of the resistant AChE, but not potent insecticides. Combination of the N-propylcarbamate with N-methylcarbamate with same or different phenyl group gave a potent synergistic insecticidal activity, and were shown to be promising insecticides for practical application. The mechanism was elusidated on biochemical basis. The AChE from resistant leafhopper has the additional site which is sensitive to N-propyl but insensitive to N-methylcarbamates other than the N-methylcarbamate-sensitive site present in AChE from susceptible leafhopper. Single inhibitor could not inhibit both sites, but combining two inhibitors, each interacts with the preferred site. Recognition of such mechanism would provide the chance for finding another chemicals and a rational basis for the use of combined anti-AChEs.
日本農薬学会の論文
1979-08-20