生体を対象とした制御システム : 降圧剤による血圧の最適制御

概要

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There has been an increasing interest in the blood-pressure control by using vaso-active drug, sodium nitroprusside (SNP), during surgery or in intensive care unit. Since SNP dose response is variable at times, it is difficult to determine fixed control law. To overcome this problem, an Optimal blood-pressure Control system with On-line Pulse Identification (OCOPI) was developed. The OCOPI has two basic functions, "on-line identification" and "the optimal control". The SNP dose response is identified by the OCOPI by using pulse SNP infusion before each starting control. Sequentially, an optimal control law is obtained based on the identification by using the dynamic programming technique and is used to regulate blood-pressure. Ex vivo evaluations of the OCOPI were carried out by using 5 mongrel dogs. To evaluate availability of on-line pulse identification, 22 cases of the identification were tested on different environment (anesthetize depth) by using one dog. To evaluate the optimal control law, 12 cases of blood-pressure regulation were performed. From ex vivo evaluation results, the OCOPI is found to be a useful system to overcome the control problem which are caused by different SNP dose responses.
公益社団法人精密工学会の論文
1989-02-05