Response to Invasion by Antigens and Effects of Threshold in an Immune Network Dynamical System Model with a Small Number of Degrees of Freedom
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概要
- 論文の詳細を見る
We study a dynamical system model of an idiotypic immune network with a small number of degrees of freedom, focusing mainly on the effect of a threshold above which antibodies can recognise antibodies. The response of the system to invasions by antigens is investigated in models both with and without such a threshold, and we find that the system changes in a desirable way for a moderate magnitude of the perturbation; that is, the system changes to a state in which the antigen is neutralized more quickly than in the unperturbed state. Also, the propagation of a disturbance caused by an antigen is investigated in a system of one-dimensionally connected basic units, taking the closed 3-clone system as a unit, and it is found that the threshold of the system has the effect of enhancing the stability of the network and to localise the immune response.
- 理論物理学刊行会の論文
- 2002-04-25
著者
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Uezu Tatsuya
Graduate School Of Human Culture Nara Women's University
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Itaya Satoko
Graduate School Of Human Culture Nara Women's University
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UEZU Tatsuya
Graduate School of Human Culture, Nara Women's University
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