情動性と副腎皮質ホルモン分泌動態との関連性(心身症における情動と内分泌5第15回日本精神身体医学会総会シンポジウム)

概要

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The two purposes of this study consist of the elucidation of the pituitary-adrenocortical response to the different kinds of emotional stimulus, and the investigation of the relationship between these responses and the hyperemotional condition produced by isolation housing.Communicated anxiety stimulus (CAS) and novel stimulus (NS) were prepared as an emotional stimulus by the apparatus of communication box and open-field test.Experimental animals were mail albino rats of Wistar-strain weighing about 250 gm. Plasma corticosterone (PCS) were determined by van der Vies' method. Experiments were always performed from 1 : 00 p. m. to 3 : 00 p. m.Following data were obtained ;1) Significant increase of PCS level was observed in almost the same degree in case of CAS and NS, but such an increasing rate was lower than in case of electric shock.2) The rate of increase in PCS level has no relation to the number of stimulus or the difference of the "cue" which mediates the input of emotional stimulus to an individual.3) The elevation of PCS was ovserved by the initial exposure of CAS or NS. In grouped rats, such an elevated PCS decreased in case of NS by repeated exposure, but did not decrease in case of CAS. In isolated rats, even in case of NS, such a decreasing pattern was not observed.4) Chlorpromazine and diazepam did not inhibit PCS response to novel stimulus.
日本心身医学会の論文
1975-02-01