PRELIMINARY EFFICACY TRIAL OF CYMELARSAN IN MICE ARTIFICIALLY INFECTED WITH TRYPANOSOMA BRUCEI BRUCEI ISOLATED FROM A DOG IN ZAMBIA

概要

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An efficacy trial of Cymelarsan on a Zambian strain of Trypanosoma brucei brucei was done. Twenty-five male mice were infected intraperitoneally with 10^6 of T. b. brucei isolated from a dog. Five groups of 5 mice were treated with 0 (control), 0.25, 0.5, 1.0 and 2.0 mg/kg Cymelarsan, respectively. The target was to achieve aparasitaemia for 30 days post-treatment, euthanising those that remained parasitaemic or relapsed before then. The 0.25 and 0.5 mg/kg groups remained parasitaemic although the parasitaemic levels were reduced. The 1.0 mg/kg group had a proportion of aparasitaemic mice. However, all mice in the 2.0 mg/kg group remained aparasitaemic until day 20 when 2 mice relapsed. These resullts suggested that more than 2.0 mg/kg was required to eliminate this strain.
北海道大学の論文
1995-09-22