Inhibition of Cytokines and ICAM-1 Induction in Rheumatoid Fibroblasts by anti-NF-kB Reagents
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概要
- 論文の詳細を見る
The role of the transcription factor, nuclear factor NF-kB, in the induction of cytokines and intercellular adhesion molecule-1 (ICAM-1) on stimulation with interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) was studied in primary rheumatoid synovial fibroblasts (RSF) obtained from patients with rheumatoid arthritis (RA). The production of GM-CSF, IL-6,and IL-8 and the expression of ICAM-1 were augmented after nuclear translocation of NF-kB induced by treatment with IL-1 or TNF-α. We examined the effects of N-acetyl-L-cysteine (NAC) and acetylsalicylic acid (aspirin) on the induction of proinflammatory cytokines and ICAM-1. Pretreatment of RSF with NAC inhibited nuclear translocation of NF-kB completely, and the induction of these cytokines and ICAM-1 was markedly suppressed. On the other hand, the effect of aspirin was only partial. These observations indicate the pivotal role of NF-kB in RA pathogenesis, thus highlighting the possibility of a novel therapeutic strategy.
- 日本医科大学の論文
- 1998-03-25
著者
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Yang Jian-ping
Department Of Molecular Genetics Nagoya City University Medical School
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OKAMOTO TAKASHI
Department of Pediatrics, Takamatsu Red Cross Hospital
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Sakurada Shinsaku
Department of Immunology and Infectious Diseases, Institute of Gerontology, Nippon Medical School
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KATO Tetsuji
Department of Molecular Genetics, Nagoya City University Medical School
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MASHIBA KOHICHI
Department of Molecular Genetics, Nagoya City University Medical School
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YANG JIANPING
Department of Molecular Genetics, Nagoya City University Medical School
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Okamoto T
Department Of Molecular And Cellular Biology Nagoya City University Graduate School Of Medical Scien
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Okamoto Takashi
Department Of Mechanical Engineering Fukuyama University
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Kato T
Department Of Molecular Genetics Nagoya City University Medical School
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Mashiba Kohichi
Department Of Molecular Genetics Nagoya City University Medical School
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Okamoto Takashi
Department Of Biological Sciences Tokyo Metropolitan University
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Sakurada Shinsaku
Department Of Molecular Genetics Nagoya City University Medical School
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Sakurada Shinsaku
Department Of Immunology And Infectious Diseases Institute Of Gerontology Nippon Medical School
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Okamoto Takashi
Department Of Animal Products National Institute Of Livestock And Grassland Science
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Okamoto Takashi
Department Of Agricultural Chemistry Faculty Of Agriculture Kinki University
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