Enantioselective Peptide Synthesis by Using the Optically Active Polymer Containing the 1-Benzyl-3-Hydroxy-5-Isobutyl-Hydantoin Structure
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概要
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The polymer containing the 1-benzyl-3-hydroxyhydantoin structure was prepared from styrene and 1-chloromethylhydantotin in order to achieve not only the act as acyl activating polymeric ester but the selective reaction using the D, L-amino acid seter. For the enantioselective peptide senthesis, the 1-benzyl-3-hydroxyhydantoin as a model compound and the 1-bernzyl-3-hydroxyhydantoin type polymer were allowed to act by two methods-the active ester method and the additive method using N, N'-dicyclohexylcarbodiimide (DCC). Optical yield was appreciated in 45%.
- 東京工芸大学の論文
著者
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Okawara Makoto
Professer Research Laboratory Of Resources Utilization Tokyo Institute Of Technology
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Okawara Makoto
Research Laboratory Of Resources Utilization Tokyo Institute Of Technology
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Teramoto Takero
Lecture Master Course Fellow And Professer Department Of Ndustrial Chemistry
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Kurosaki Toshikazu
Lecture Master Course Fellow And Professer Department Of Ndustrial Chemistry
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Kurosaki Toshikazu
Department Of Industrial Chemistry Faculty Of Engineering Tokyo Institute Of Polytechnics
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TERAMOTO Takero
Department of Industrial Chemistry
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