トリチウム水の放射線化学および放射線生物学

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A building was recently constructed which has facilities specially designed for exclusive use of HTO studies. As chemical evidences of HTO, a specific UV spectrum, the luminescence exhibition only with luminol but without peroxydase and the epoxide formation from mesityl oxide were found, from which it was concluded that the radiolytic reaction of water with HTO is [H2O→H2O*→H2＋O ] followed by [O＋M→(MO),(MO)＋H2O→M(OH) 2 or ・MOH＋・OH], [O＋O→O2] and [O＋H2O→H2O2]. This was supported by low oxygen effects observed in thymine and adenine radiolysis with HTO. Low-dose-rate effect (Kada effect) was reconfirmed using the transfection system of M13 phage DNA irradiated, and then it could be explained by that the ratios of [O＋M→(MO),(MO)＋H2O→M(OH) 2 or ・MOH＋・OH] to [O＋O→O2] increases with the decrease of dose rate. RBE higher than one was obtained also in the case of the killing of radioresistant E.coil TG1. It was concluded that this is due to the high reactivity of nascent O which can act resembling two OH LD50/30 was estimated to be 5.6x108Bq (8Gy) for C57BL/6N female young mice and 9.3x108 Bq (13Gy) for (C57BL/6NxC3H/He) F1 young female mice by single-injection of HTO. At doses lower than 5.6x108 Bq (8Gy), mice died inducing leukemias with higher doses and other solid tumors with lower doses. In continuous administration of HTO, (C57BL/6NxC3H/He) F1 female adult mice died of haematopoietic failure with in 50 days at dose rates more than 0.48 Gy/day, while the appearance of lymphomas changed to that of various non-lymphoma tumors with the decrease of dose rate to less than 0.24 Gy/day and surviving over 150 days.
富山大学の論文

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山本修
広島大学理学部生物学科

トリチウム水の放射線化学および放射線生物学

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