顆粒球エラスターゼによりFDPが高値を示したと考えられるDICおよび非DIC症例の検討

概要

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Granulocyte elastase (GEL)-α\-antitrypsin complex (EAT) levels were determined by enzyme immunoassay in plasmas from twelve patients with disseminated intravascular coagulation (DIC) and eight recipients of living related liver transplantation (LLT), and compared with neutrophil counts, C-reactive protein (CRP) concentrations, and coagulation profiles. In two DIC patients and one LLT recipient, fibrin and/or fibrinogen degradation products (FDP) levels fluctuated several days after the EAT levels changed without remarkable plasmin activation. Therefore, elevated levels of FDP in these patients presumably resulted from degradation of fibrin and/or fibrinogen by activated GEL However, in most of the cases, changes in EAT level were not in parallel with those in peripheral neutrophil count and/or CRP concentration. These findings raised the possibility that the elevated levels of GEL and EAT in patients with DIC and recipient of LLT were derived from activation of neutrophils by underlying conditions. We suggest that EAT is a novel, useful parameter reflecting neutrophil activation and inflammatory conditions.
信州大学の論文