<研究論文>骨格筋の強縮に伴う水のダイナミクス

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Dielectric relaxation measurements by the use of a time domain reflectometry method were performed on Gastrocnemius Muscle of Rana catesbeiana to examine the roll of water in the muscle cell. The muscle in vivo is measured at rest, on tetanus by electric impulse and after tetanus. At the same time, the bolld flow, number denstity of red blood cells and temperature are also measured by the laser flow meter and thermocouple, respectively. Four dielectric relaxation processes could be found around 1.6KHz, 40KHz, 100MHz and 13GHz, respectively, which are assigned electrode prlarization, migration of counterion on biomaterial, orientation of bound water and orientation of free water, respectively. On tetanous, the free water increases by 3.3% compared with that at rest, and at 30 and 55 minutes after tetanus it increases by 7.9% and 9.4% respectively. On the other hand, the blood flow and number density of red blood cells decreases at 55 minutes after tetanus. These results indicate that the increase of free water is not caused by the blood flow and number density of red blood cells, but by the generation of water by aerobic glycolysis, and also by the ooze of water from a blood vessel to muscle cell by concentration gradient brought from generation latic acid by anaerobic glycolysis. Amount of bound water on tetanus increases by 59%. However, after tetanus it returns to the value at rest. The relaxation time to tetanus increases too. Thrse results suggests that the conformational change of the protein in Myofibrils has a relation to the bound water in muscle cell.
東海大学の論文

<研究論文>骨格筋の強縮に伴う水のダイナミクス

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