<論文>ラット肝臓ホモジネート中におけるD-システノール酸の代謝

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The enzymatic formation of D-cysteinolic aicd conjugated chenodeoxycholic acid in rat liver was investigated. [^<14>C] Chenodeoxycholic acid was incubated with taurine, glycine and D-cysteinolic acid in the presence of CoA, ATP, NAD^+ and FAD. The rat liver homogenate utilized both taurine and glycine as its substrate to form corresponding conjugated bile acids readily. However, little formation of chenodeoxycholyl-D-cysteinolic acid was observed when D-cysteinolic acid was incubated with bile acid. And moreover, the increased production of chenodeoxycholyltaurine was found in proportion to the D-cysteinolic acid concentration in the incubation mixture. These data suggests that D-cysteinolic acid is transformed into taurine prior to conjugation with bile acids in rat liver.
沼津工業高等専門学校の論文
1998-01-31