仔馬のパラチフス症に關する研究 : III. 馬流産菌に對する仔馬の血清反應に就いて
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Investigation was conducted to learn the transference of antibodies from mare to foal. At the same time, investigation was made on how antibodies develop in foals infected naturally or artificially with living abortion bacilli, and also in foals vaccinated with killed abortion bacilli. In conclusion, discussion was offered on the serological diagnosis in foals infected with abortion bacilli. The results obtained are summarized as follows : (1). Maternal agglutinin and complement fixing antibody transfer rapidly to the newly-born foal through the colostrum. These antibodies which transfered to the newly-born foal through the milk, usually apper in parallel in the blood of foals, and, even when the foals are continuously nursed with the milk, both antibodies disappear or diminish to normal level after about 60 days. (Table 1,2 and 3). (2). When foals of less than 60-70 days after birth are infected with abortion bacilli, there is a tendency for the agglutinin not to be present but the complement fixing antibody develops. (Table 5 and 7). On the contrary, in the foals infected at the age more than 70 days after birth, not only the complement fixing antibody, but also the agglutinin and the precipitin develop remarkably in parallel. (Table 6 and 7). The above mentioned results were similarly demonstrated too in the foals vaccinated with killed abortion bacilli. (Table. 8). (3). If one desires to diagnose by the serological method whether suckling foals under 70 days of age have been infected or not with abortion bacilli, taking the above mentioned two items into consideration, at first, it is necessary to ascertain whether the mother mare had been inoculated or not with vaccine and whether the foal had sucked or not the colostrum of immunized mare, that is, one must understand in advance the reference of transfer of antibodies from mother mare to her foal. If the mother mare had not been vaccinated, one must necessarily carry out the complement fixation test with serum of infected foal. However, when the foal had sucked the colostrum of immunized mother mare, or had been inoculated with vaccine, it is impossible to diagnose by the serological method whether the foal has been infected or not. On the contrary, if the infected foal was already more than 70 days old and had not been inoculated with vaccine, it is not needful to consider the transfer of passive antibodies to the foal from the mare; moreover, it is easy to diagnose by means of the agglutination or the preciptation test which are more simple methods than the complement fixation test.
- 北海道大学の論文
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