<治療に関する研究>未熟心筋に対する心筋保護法の検討

概要

論文の詳細を見る
In the present study. the efficacy of crystalloid cardioplegia (St. Thomas' hospital solution : ST) and cold blood cardioplegia (CBC) in the neonatal heart were investigated to determine whether responses to frequent administration of each cardioplegic solution would be the same. Isolated neonatal rabbit hearts were subjected to 3 hours of global ischemia at 15℃ and treated with ST or CBC. Each solution was administered in a single-dose or multiple-doses every 60,30 and 15 minutes during ischemia. High energy phosphate levels were measured at the end of ischemia and during reperfusion by ^<31-> phosphorus nuclear magnetic resonance in each group. After 30 minutes of reperfusion, in the ST groups, recovery of the ATP level was best in the ST-single group. Conversely, in the CBC groups, recovery of the ATP level was best in CBC-15 group. Multidose administration of ST showed a detrimental effect ; in contract, CBC had a benefical effect on the myocardial preservation and recovery of the ATP level in the neonatal heart. The lack of free radical scavenger, not the lack of oncotic pressure, in ST might have caused the deleterious effects during frequent infusion of ST in the neonatal heart.
近畿大学の論文
1994-12-30