<原著>大腸癌に対する放射線化学療法の臨床効果と基礎的細胞動態の解析

概要

論文の詳細を見る
To evaluate the effectiveness of preoperative chemo-radiation therapy for colorectal cancer patients. Twenty patients with colorectal cancer were allocated for treatment by preoperative radiation therapy (RT group ; 7 cases), chemotherapy (5-FU group ; 5 cases) or combination therapy (RT and 5-FU group ; 8 cases), and the DNA ploidy pattern from fresh material were compared before and aftere treatment. Change in DNA ploidy pattern from DNA-aneuploidy to DNA-diploidy was observed in 33.3% of the RT alone cases, 66.7% of the 5-FU alone cases and 100% of the combined group. On histological evaluation, the combined group also showed changes (p<0.05). To examine the mechanism of this combination therapy, cell-kinetics were investigated using four colorectal cell lines. There were 3 types mechanism ; the enhancing effect of 5-FU (accumulated S phase), of radiation (accumulated G2+M phase), and the enhanced combined effect by chemo-radiation therapy
近畿大学の論文
1994-09-25