<原著>凍結脳損傷時のグリア細胞に対するマクロファージ, インターロイキン-1の影響 : 免疫組織学的検討
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The relationship between monocyte-macrophage and neuroglial cells was investigated using immunohistochemical methods in early stage of a gerbil brain cold injury model. Anti-macrophage antisera immunopositive monocyte-derived macrophage appeared at 1 day after cold injury in the necrotic lesion, and numbers of the reacted macrophage reached a maximum at 5 days. Ricinus communis agglutinin-1 lectin (RCA-1) labeled microglia appeared at 1 day, and numbers of the reacted microglia reached a maximum at 3 days at the cortex around the lesion. Anti-GFAP antisera immunopositive reactive astrocytes appeared at 2 days, the number of reacted astrocytes reached a maximum at 5 days. Marked decrease of infiltration of macrophages into the lesion, followed by decrease in the numbers of microglia and astrocytes around the lesion, was visualized in the lesions after myelosuppression by irradiation. In addition delay of reaction of glia cells resulted in the delay of tissue repair in irradiated animals. After administration of interleukin-1 (IL-1) in irradiated animals, anti-GFAP immunopositive reactive astrocytes appeared around the lesion at the second day. The number of reactive astrocytes and intensity of immunoreactivity was significantly increased compared with those in the nontreated group, and reached a maximum at 5 days. However, the number of microglia in the treated group was decreased in comparison with that in the non-treated group throughout the entire experimental period. These findings suggest that IL-1 is derived mainly from monocyte-macrophages, and is effective against the proliferation and maturation of reactive astrocytes and tissue repair.
- 近畿大学の論文
- 1993-09-25
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