<原著>魚油摂取ラットにおけるエンドトキシン投与の影響
スポンサーリンク
概要
- 論文の詳細を見る
Eicosapentaenoic acid (EPA) is believed to be responsible for the anti-inflammatory activity of fish oil. However, EPA also causes production of a lipid peroxide (LPO) in vivo because it has one more double bond than arachidonic acid (AA). We studied both effects of fish oil on administered lipopolysaccharide (LPS). Male Wistar rats were allowed to take a low-fat feed containing 15% cod-liver oil (FO Group) or 15% safflower oil (SO Group) for 6 weeks and then administered intraperitoneally 10 mg/kg of LPS. Controls were given physiological saline alone. Blood and liver-tissue leukotriene B_4 (LTB_4) and LPO were determined 2 and 4 hours after administration of LPS or saline. LPS significantly enhanced blood LTB_4 levels (pg/ml) 4 houns after administration in comparison with the saline administered group : significantly higher levels in the SO Group (1,313.0±389.6,n=8) than in the FO Group (594.0±151.7,n=7) (p<0.001 ). White blood cell count (WBC; /mm^3) was lowered in the SO Group than in the FO Group 4 hours after administration of LPS (2,013±422 vs 3,200±697,p<0.01). The concentration of LTB_4 varied in liver tissue (pg/wet・g) as well as in blood (425.3±96.0 in the FO Group (n=7) ; 704.8±117.8 in the SO Group (n=8), p<0.001). Plasma GOT and GPT indicated more severe hepatic dysfunction in the FO Group. The FO Group showed significantly higher LPO levels in plasma and liver tissue prior to LPS administration (p<0.001 in both). These findings suggested that dietary-fish-oil feeding lowered the levels of LTB_4 and reduction of WBC induced by LPS while it increased the accumulation of LPO and that it aggravated hepatic disorder caused by LPS.
- 近畿大学の論文
- 1992-03-25
著者
関連論文
- 25. 再発部局所切除後4年2カ月生存中の下部胆管癌の1例(第16回日本胆道外科研究会)
- 20.エンドトキシン投与ラットにおける血中ロイコトリエンB_4(LTB_4)および白血球数におよぼす魚油の影響
- 259 膵仮性嚢胞症例についての検討(第37回日本消化器外科学会総会)
- 325 十二指腸傍乳頭憩室合併の胆石症例における胆汁中β-グルクロニダーゼおよび膵酵素活性(第36回日本消化器外科学会総会)
- 無黄疸期に発見された下部胆管癌および十二指腸乳頭部癌について
- 脾温存膵尾側切除の1例とその考察
- 播種性血管内凝固症候群に合併した後腹膜巨大血腫の1例
- Mirizzi 症候群の7例
- 299 脾温存膵切除の経験(第31回日本消化器外科学会総会)
- 原発性胆嚢管癌の1例
- Mirizzi症候群
- 脾内進展を示した膵尾部癌の1切除例
- Freyの手術が有効であった膵性腹水の1例
- II-S7. QOL と延命効果からみた食道非切除進行癌の治療成績(第47回食道疾患研究会)
- 示-162 きわめて急速な発育を示した胃 Endocrine cell carcinoma の一症例(第42回日本消化器外科学会総会)
- 魚油摂取ラットにおけるエンドトキシン投与の影響