<原著>上部消化管穿孔におけるGastrografin testの基礎的検討 : 尿中アミドトリゾ酸の測定方法

概要

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As a basis for the Gastrografin^<[○!R]> test in the early diagnosis of perforation in the upper gastrointestinal tract, we measured urinary amidotrizoate, an active ingredient of Gastrografin^<[○!R]>. We compared the sensitivity, reproducibility and convenience of detection among for methods determining urinary amidotrizoate, i.e., (1) the acid precipitation method using hydrochloric acid, (2) thin layer chromatography (TLC), (3) reductive decomposition/chroloform colorimetry, and (4) inductively coupled plasma (ICP) emission spectrophotometry. Except for the acid precipitation method, all methods were useful for detection of urinary amidotrizoate with satisfactory specificity and accuracy. TLC was very sensitive for the identification of amidotrizoate, but it was considered to be too complicated for routine use. Reductive decomposition/chroloform colorimetry was relatively simple and convenient, and could be used in the clinical laboratory. ICP emission spectrophotometry was the most sensitive and accurate, and it was most convenient for detection of urinary amidotrizoate in large numbers of samples, but it required special expensive equipment.
近畿大学の論文
1990-12-25