<原著>自己免疫性甲状腺疾患におけるガストリン値の動態 : 抗壁細胞抗体とガストリン値

概要

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It was disclosed in previous study that fasting serum gastrin levels in Graves' disease were so variously distributed, and consequently suggested that the hypergastrinemia could not result simply from the effects of thyroid hormones on gastrin levels. In this report, measurement of parietal cell antibody (PCA) were widely performed in patients with Graves' disease and chronic thyroiditis and interrelations between PCA, fasting serum gastrin levels, maximum acid output (MAO) and thyroid functions were discussed to clarify the mechanism of hypergastrinemia in Graves' disease. Since positive incidence of PCA in both Graves' disease and chronic thyroiditis was significantly higher than respective value in sex and age-matched controls, measurements of PCA are especially important to clarify the mechanism of hypergastrinemia. It was concluded that PCA had a role in controlling the hypergastrinemia in Graves' disease. On the other hand, since fasting serum gastrin levels had a tendency to elevate in hyperthyroid patients with PCA-negative Graves' disease either, thyroid hormone-induced gastric effects, for instance, decrease of gastric acid output capacity would be another factor determining fasting serum gastrin levels in Graves' disease.
近畿大学の論文
1984-03-25