<原著>食細胞を脱核するプリン体のマクロファージ機能および形態に対する効果

概要

論文の詳細を見る
The authors previously reported that purine compounds, such as adenine, guanine, adenosine and guanosine, had an ability to enucleate exclusively macrophages and polymorphonuclear cells. In contrast to that, cytochalasin B (CB) has been known to exhibit the enucleation activity for various kinds of cells. CB also induces the morphological change of cells and affects the cellular function, which results from the inhibition of actinfilament elongation. In this report, the authors showed that the purine compounds caused morphological changes of macrophages (cell spreading, elongation, or rounding) and inhibited the phagocytic activity by short term cultivation (1 or 3h) with the cells. It is likely that the purine compounds directly or indirectly affect cytoskeletons to induce the enucleation, the morphological change, and the inhibition of phagocytic activity of macrophages.
近畿大学の論文
1988-09-25