<原著>2-クロルアデノシンのマクロファージ形態変化に及ぼす影響

概要

論文の詳細を見る
2-Chloroadenosine has been known to exert the selective lethal effect on macrophages. We also reported that the rapid decrease of intracellular ATP was responsible for the cell death of macrophages. Several investigators used the reagent as the selective inhibitor and eliminator on in vitro immunological responses. In the present study, we tested the effect of 2-chloroadenosine on the cell spreading of macrophage. 2-Chloroadenosine induced a morphological effect resulting in cell roundation on the macrophages spread with LPS or subtilisin. The cell roundation was reversible when adenosine, which prevented the lethal effect of 2-chloroadenosine and restored the ATP level, was added after the treatment of macrophages with 2-chloroadenosine. The results suggest that the cell roundation in 2-chloroadenosine-treated macrophages is caused by the decrease of ATP level.
近畿大学の論文
1988-03-25