<原著>甲状腺自己抗体陽性者の精神障害について

概要

論文の詳細を見る
Nine psychotic patients with thyroidal autoantibodies in their circulating blood, which were either anti-microsomal or anti-thyroglobulin antibody, are described at large. It resulted that the psychotic patients who had thyroidal autoantibodies were rather small in number (2%). Moreover there was a definite sexual difference, namely, remarkably high incidence in female. It is proved that thyroid autoantibodies affect the onset of the psychotic breakdown through plasma thyroid hormone level. However its direct effect to psychotic breakdown could not be recognized this time. In case that the titer of the thyroid autoantibodies was higher, the abnormality of plasma thyroid hormone level became significant (either hypothyroid or hyperthyroid state) and there noted a tendency that the onset of psychotic breakdown was rather acute. On the other hand, in case of lower titer, the abnormality of plasma thyroid hormone level did not become so significant. Also there was a tendency that the onset of psychotic breakdown was rather chronic. In addition, the autoimmune hypothesis of psychosis that greatest impetus to the concept of psychosis as an autoimmune disease has arisen from the controversial work of Heath in 1956 is also described here chronologically in brief.
近畿大学の論文
1983-03-25