低たん白食によるラットの肝硬変発症時における血液性牡と肝細胞組織(B. 生活科学)

概要

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We conducted to estimate hematological and metabolic changes in the productive process of hepatic cirrhosis. Male Charles-River Crj-CD rats were fed 5% gluten diet, 5% casein diet, 5% wheat-pattern amino acid mixture diet and 20% casein diet as control ad libitum for 29 weeks. After autopsy, hematological and biochemical determinations were performed. Body weight gains of rats on experimental low protein diets were significantly lower than that of the control, showing 82g for LC-group, 12g for W-group and -6g for G-group as compared with 420g of the control group at the 20th experimental week. At the 29th experimental week, rats in W-and G-groups showed significant decreases in RBC counts, hemoglobin contents, hematocrits and serum protein. On the same week, RNA, DNA contents and RNA/DNA ratios in rat liver tissues of W-group and G-group did not differ from those of the control group. For LC-group, however, collagen contents in the liver had a tendency to slightly increase. These biochemical evidences were co-ordinate to histological findings.
京都府立大学の論文
1989-11-18