コリン含有低たん白飼料長期投与ラットに発症した肝硬変について(B. 生活科学)

概要

論文の詳細を見る
The influences of dietary protein qualities on resulting in rat liver cirrhosis were studied. Male Charles River CRJ SD rats were fed 5% gluten diet (G group) or 5% casein (LC group) and 20% casein diet (control) ad libitum for long periods (25 weeks more). These diets contained adequate amounts of mineral and vitamins, especially with 0.2 to 0.4% choline chloride. After autopsy, histochemical determination was performed. Body weight gains of LC and G rats were significantly lower than that of the control. The experimental rats died at the 26th and 39th experimental week for LC rats and at the 123rd experimental week for G rat, respectively. Microscopically, LC rat liver occurred degeneration and massive necrosis showing remnants of hepatocytes in destructive masses with regenerative hepatic cells, hyperplasia of connective tissues and bile duct proliferation. In G rat liver, parenchyma was fatty degenerative and was surrounded and traversed by collagenous septa. From these finding, it was suggested that rat hepatic cirrhosis caused by low protein diets with choline was early observed for LC rats and later in periods for G rat.
京都府立大学の論文
1988-11-18