<原著>糖尿病患者における高温下thyrotropin-releasing hormone (TRH)負荷試験による発汗機能の検討

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The mechanisms of sweat disturbance in diabetic patients were studied by inducing thermal sweating and measuring changes in sweat rate following the administration of thyrotropin-releasing hormone (TRH). In 7 diabetic patients (DM)(4 males and 3 females, 1 Type 1 and 6 Type 2) and 6 sex- and age-matched normal control subjects (C), sweat rate was quantitatively recorded in the forearm and the thigh under a hot environment of 40℃, 40% RH. Tympanic temperature (Tty) was also recorded as a core temperature. Synchronous sweat expulsions, which represent the effector responses to sympathetic sudomotor burst activity, were identified on sweat rate curves, and their rate was calculated. TRH administration (0.5 mg, i. v.) immediately increased the sweating, which was accompanied by a reduction of Tty both in C and DM groups. The rate of increased sweating following TRH was greater in the forearm than in the thigh in both C and DM groups. The frequency of sweat expulsions (Fsw) was also increased by TRH administration, with no significant difference in the rate of increase between C and DM groups. Sweat rate/Fsw, which reflects the sensitivity of sweat glands (peripheral sudomotor mechanism) to sudomotor burst activity was, increased by TRH administration both in the forearm and the thigh in both C and DM groups, but the rate of increase was significant only in the forearm in the DM group. The results indicate that in the forearm of the DM group the sensitivity of sweat glands was increased when sudomotor activity was enhanced by TRH. This suggested that in diabetic patients denervation supersensitity of sweat glands is present on the upper arm and the upper trunk, which may contribute at least in part to the hyperhidrosis of these skin areas in diabetic patients.
愛知医科大学の論文
2002-12-15

<原著>糖尿病患者における高温下thyrotropin-releasing hormone (TRH)負荷試験による発汗機能の検討

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