臨床検査の進歩 : 糖尿病の検査を例に挙げて

概要

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The 'Ebers Papyrus' possibly represents the first known medical text describing diabetes and its treatment. Sweetness of urine was recorded in old India and China. The term 'diabetes' was introduced into medical nomenclature by Aretaeos of Kapadokya in 1 st century. After the Renaissance many workers described sweetness of urine and demonstrated the sweet substance in urine to be glucose. In 1864,Langerhans discovered the islet cell of pancreas. Von Mehring and Minkowski observed diabetes in pancreatectomized dog in 1889. In 1921,Banting and Best discovered insulin dramatically. After discovery of insulin, basic and clinical investigations of diabetes mellitus progressively expanded ; discovery of insulin structure, discovery of proinsulin, development of radioimmunoassay of insulin and synthesis of insulin. Recently, diabetic studies have been vigorously conducted in molecular searches for insulin receptor, postreceptor insulin-signal transmission, glucose transporter, autoimmunity in diabetes, glycosylation of proteins and gene mutation.
香川県立保健医療大学の論文