EFFECTS OF INSULIN ON NITRIC OXIDE PRODUCTION IN CULTURED HUMAN ENDOTHELIAL CELLS
スポンサーリンク
概要
- 論文の詳細を見る
It has been reported that insulin treatment improves hypertension in the patients with diabetes mellitus. The mechanisms of the antihypertensive effect of insulin, however, remains to be fully elucidated. Nitric oxide (NO) is generated in the endothelial cells and tonically regulates blood pressure. In the present study, we investigated the effect of insulin on NO production in cultured human endothelial cells. Insulin (1μM, 10μM and 100μM) increased NO metabolite (NO_2^-) levels in the medium and NO synthase (NOS) activity in cultured human endothelial cells. Insulin also stimulated proliferation and mitogen-associated protein kinase activity of the endothelial cells. These findings suggest that insulin reduces blood pressure by stimulating NO production in the endothelial cells, possibly via induction of NOS molecule and proliferation of endothelial cells.
- 島根大学の論文
著者
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Kato Y
Department Of Endocrinology Metabolism And Hematological Oncology School Of Medicine Shimane Univers
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Kato Yuzuru
島根大学 医学部内分泌代謝・血液腫瘍内科
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Kato Yuzuru
島根大学 医学部内分泌代謝･血液腫瘍内科
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Kawaguchi Mikiko
First Division Department Of Medicine Shimane Medical University
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Koshimura Kunio
First Division, Department of Medicine, Shimane Medical University
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Murakami Yoshio
First Division, Department of Medicine, Shimane Medical University
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Tsumori Michihiro
First Division, Department of Medicine, Shimane Medical University
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Kato Yuzuru
First Division, Department of Medicine, Shimane Medical University
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Kato Yuzuru
First Division Department Of Medicine Shimane Medical University
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Mori T
First Division Department Of Medicine Shimane Medical University
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Tsumori Michihiro
First Division Department Of Medicine Shimane Medical University
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Murakami Yoshio
Division Of Cardiovascular Medicine Department Of Internal Medicine Shimane University School Of Med
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KOSHIMURA Kunio
Department of Endocrinology, Metabolism and Hematology, Shimane University School of Medicine
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Koshimura Kunio
First Division Department Of Medicine Shimane Medical University
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Kato Yuzuru
First Division Department Of Medicine Shiman Medical University
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