Correlations among bone mineral density, insulin-like growth factors and biochemical bone markers in healhty female subjects
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概要
- 論文の詳細を見る
Insulin-like growth factor-I (IGF-I) is an anabolic factor for osteoblasts. A positive relationship between bone mineral density (BMD) and circulating IGF-I levels suggest that IGF-I has an endocrine effect on increasing bone mass. In this study, plasma IGF-I and IGF-II were determined in relation to BMD and biochemical bone markers in 228 healthy female subjects. Both BMD and plasma IGF-I levels declined with age. There was no significant correlation between plasma IGF-I levels and BMD, and between plasma IGF-I levels and either plasma carboxy-terminal propeptide of type I procollagen (PICP) or pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) levels. It is suggested, therefore, that the decline in plasma IGF-I levels has little contribution to the decrease in BMD in healthy aged women and that the agerelated decrease in plasma IGF-I levels are not associated with changes in biochemical bone markers.
- 島根大学の論文
著者
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Kato Y
Department Of Endocrinology Metabolism And Hematological Oncology School Of Medicine Shimane Univers
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Kato Yuzuru
島根大学 医学部内分泌代謝・血液腫瘍内科
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Kato Yuzuru
島根大学 医学部内分泌代謝･血液腫瘍内科
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Murakami Yoshio
First Division, Department of Medicine, Shimane Medical University
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Kato Yuzuru
First Division Department Of Medicine Shimane Medical University
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SOHMIYA Motoi
First Division, Department of Medicine, Shimane Medical University
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Murakami Yoshio
Division Of Cardiovascular Medicine Department Of Internal Medicine Shimane University School Of Med
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SUGITANI Miyoko
First Division, Department of Medicine, Shimane Medical University
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Sugitani Miyoko
First Division Department Of Medicine Shimane Medical University
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Kato Yuzuru
First Division Department Of Medicine Shiman Medical University
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