<SYMPOSIUM : Biology of Aging and Age-associated Skin Disorders>TELOMERASE ACTIVITY, P53 VS BCL-2 EXPRESSION AND APOPTOSIS IN HUMAN SKIN CANCERS
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概要
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In this study we examined telomerase activity of skin tumors and normal skin tissues quantitatively and found that malignant skin tumors had generally high telomerase activity, while benign skin tumors and normal skin tissues had no or low telomerase activity. Among malignant skin tumors basal cell carcinomas had much higher telomerase activity than the others. In addition, the level of telomerase activity of the other keratinocyte-originated tumors (actinic keratosis, Bowen's disease, squamous cell carcinoma) showed close relation to their malignancy. p53 protein expression appears to increase the rate of apoptosis, especially in basal cell carcinomas and squamous cell carcinomas on sun-exposed sites. bcl-2 protein expression was shown strongly in malignant melanoma, but did not reduce the rate of apoptosis. There was no relation between the telomerase activity and p53 or bcl-2 protein expression in the skin tumors as well as apoptosis.
- 名古屋市立大学の論文
- 2000-01-31
著者
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TSUJI Takuo
Department of Dermatology, Nagoya City University Medical School
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Tsuji Takuo
Department Of Dermatology Nagoya City University Medical School
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SAKAKIBARA Noriyuki
Department of Dermatology, Nagoya City University, Medical School Nagoya
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NAKAJIMA Masaru
Department of Dermatology, Nagoya City University Medical School
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HISATOMI Hisashi
Center for Molecular Biology and Cytogenetics, SRL, Inc.
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Hisatomi H
Center For Molecular Biology And Cytogenetics Srl Inc.
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Hisatomi Hisashi
Center For Molecular Biology And Cytogenetics
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Sakakibara Noriyuki
Department Of Dermatology Nagoya City University Medical School
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Nakajima Masaru
Department Of Dermatology Nagoya City University Medical School
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